Occupational safety and health
Trichloroethylene and Perchloroethylene Work
Trichloroethylene and Perchloroethylene Work

Health Hazards

Trichloroethylene

Acute:
Inhalation:
1.1 At concentrations above 30 ppm, vapors irritate the nasal and throat mucosa.
1.2 At concentrations between 100-600 ppm, the central nervous system may be suppressed, causing dizziness, headaches, nausea, and excessive fatigue.
1.3 High concentrations (above 1000 ppm) can cause loss of consciousness, tremors, muscle coordination loss, vision abnormalities, and arrhythmia.
Skin:
2.1 Prolonged contact with liquid can cause severe irritation and dermatitis.
2.2 Reports indicate that high concentrations may cause chemical burns.
Eyes:
3.1 Trichloroethylene vapors can irritate the eyes.
3.2 Trichloroethylene liquid can cause corneal damage, but it is reversible.
Ingestion: Can cause vomiting, diarrhea, heart failure, pulmonary hemorrhage, nervous system damage, and blindness.

Chronic:
Reports indicate long-term exposure can cause irritant dermatitis, liver damage, and behavioral problems.
It may cause nervous system damage, characterized by tremors, dizziness, anxiety, bradycardia (slow heart rate), reduced sensation in the hands, and insomnia.
Exposure to high concentrations (100-630 ppm) can reduce male sexual capacity. Women may experience irregular menstruation, and it can disrupt the nervous system.
It may lead to kidney cancer and potentially trigger liver and lymphatic cancers.

Perchloroethylene

Acute:
Inhalation:
1.1 At concentrations between 200-500 ppm, vapors irritate the eyes, nose, and throat.
1.2 At concentrations between 1000-2000 ppm, it can damage the liver and kidneys, and suppress the central nervous system. Symptoms include nausea, headaches, loss of appetite, confusion, dizziness, and unconsciousness.
1.3 Accidental overexposure may result in death.
Skin:
2.1 Absorbed through the skin, but insignificantly.
2.2 Prolonged exposure can cause redness, heat, and blistering.
Eyes:
3.1 High concentration vapors cause mild irritation.
3.2 Splashing can cause pain, burns, and tearing but no permanent damage.
Ingestion: Ingesting 2.8-4 ml (about 4.2-6 g) can cause euphoria and symptoms of drunkenness.

Chronic:
Long-term overexposure may affect the nervous system, with symptoms including confusion, poor memory, hand tremors, poor vision, and finger numbness.
Long-term exposure can cause skin irritation, dryness, dermatitis, and peeling.
Prolonged overexposure may sometimes damage the liver.
It accumulates in fat tissues for a period, typically excreted through breathing or metabolized to trichloroacetic acid and excreted in urine.
Increased incidence of lung, skin, and cervical cancers; limited literature is available.
If breast milk is contaminated, infants may experience jaundice and liver enlargement, but recovery occurs after breastfeeding stops.
Increased risk of bladder cancer, multiple myeloma, or non-Hodgkin lymphoma.

Suggestions:
Level 1 Management: No specific regulations.
Level 2-4 Management:
Consider health conditions unsuitable for this type of work, such as chronic hepatitis, alcoholic hepatitis, kidney diseases, cardiovascular diseases, neurological disorders, contact dermatitis, and health protection for pregnant workers.