乳酸脱氫酶 LDH
Lactate Dehydrogenase (LDH): Marker for Tissue Damage
*Lactate dehydrogenase (LDH) is an intracellular enzyme involved in energy metabolism, found in various tissues such as the liver, heart, muscles, kidneys, and blood. Elevated LDH often indicates cellular damage or disease, making it a crucial marker for assessing tissue injury.
*Normal Range
Adults: 124-222 U/L
*Causes of Elevated LDH
-Tissue Damage:
Heart: Myocardial infarction.
Liver: Hepatitis, cirrhosis, or liver tumors.
Kidneys: Kidney disease or failure.
-Blood Disorders:
Hemolytic anemia, leukemia, or malignant lymphoma.
-Muscle Diseases:
Muscle injuries, myositis, or rhabdomyolysis.
-Cancers:
Tissue destruction associated with cancer or metastatic tumors.
-Other Causes:
Severe infections, hypoxia (e.g., shock), or acute pancreatitis.
*Clinical Significance
-Elevated LDH Levels:
Indicate cellular damage and should be interpreted alongside other tests (e.g., cardiac enzymes, liver and kidney function).
-Abnormal LDH Isoenzymes:
Different LDH isoforms help pinpoint the affected tissue. For example:
LDH1: Associated with heart damage.
LDH5: Linked to liver damage.
*How to Reduce LDH Levels?
-Treat Underlying Conditions:
Identify and address the root cause of elevated LDH, such as infection, cancer, or hemolysis.
-Adopt a Healthy Lifestyle:
Balanced diet and moderation in alcohol intake to minimize liver and kidney strain.
-Prevent Tissue Damage:
Avoid intense physical exertion or injuries, particularly for individuals with chronic illnesses.
-Regular Monitoring:
Blood disorders or cancer patients should monitor LDH levels to track disease progression or treatment response.
*Conclusion
LDH is a vital marker for cellular damage and disease. Elevated levels signal potential tissue injury or underlying health issues. Managing the underlying conditions, maintaining a healthy lifestyle, and regular monitoring can effectively manage LDH levels. Seek medical attention for abnormal results to ensure timely diagnosis and treatment.
*Lactate dehydrogenase (LDH) is an intracellular enzyme involved in energy metabolism, found in various tissues such as the liver, heart, muscles, kidneys, and blood. Elevated LDH often indicates cellular damage or disease, making it a crucial marker for assessing tissue injury.
*Normal Range
Adults: 124-222 U/L
*Causes of Elevated LDH
-Tissue Damage:
Heart: Myocardial infarction.
Liver: Hepatitis, cirrhosis, or liver tumors.
Kidneys: Kidney disease or failure.
-Blood Disorders:
Hemolytic anemia, leukemia, or malignant lymphoma.
-Muscle Diseases:
Muscle injuries, myositis, or rhabdomyolysis.
-Cancers:
Tissue destruction associated with cancer or metastatic tumors.
-Other Causes:
Severe infections, hypoxia (e.g., shock), or acute pancreatitis.
*Clinical Significance
-Elevated LDH Levels:
Indicate cellular damage and should be interpreted alongside other tests (e.g., cardiac enzymes, liver and kidney function).
-Abnormal LDH Isoenzymes:
Different LDH isoforms help pinpoint the affected tissue. For example:
LDH1: Associated with heart damage.
LDH5: Linked to liver damage.
*How to Reduce LDH Levels?
-Treat Underlying Conditions:
Identify and address the root cause of elevated LDH, such as infection, cancer, or hemolysis.
-Adopt a Healthy Lifestyle:
Balanced diet and moderation in alcohol intake to minimize liver and kidney strain.
-Prevent Tissue Damage:
Avoid intense physical exertion or injuries, particularly for individuals with chronic illnesses.
-Regular Monitoring:
Blood disorders or cancer patients should monitor LDH levels to track disease progression or treatment response.
*Conclusion
LDH is a vital marker for cellular damage and disease. Elevated levels signal potential tissue injury or underlying health issues. Managing the underlying conditions, maintaining a healthy lifestyle, and regular monitoring can effectively manage LDH levels. Seek medical attention for abnormal results to ensure timely diagnosis and treatment.